Modeling residue usage in aligned protein sequences via maximum likelihood
نویسندگان
چکیده
منابع مشابه
Modeling residue usage in aligned protein sequences via maximum likelihood.
A computational method is presented for characterizing residue usage, i.e., site-specific residue frequencies, in aligned protein sequences. The method obtains frequency estimates that maximize the likelihood of the sequences in a simple model for sequence evolution, given a tree or a set of candidate trees computed by other methods. These maximum-likelihood frequencies constitute a profile of ...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 1996
ISSN: 0737-4038,1537-1719
DOI: 10.1093/oxfordjournals.molbev.a025583